Nwokorie, Chukwuma Chigozie; Ezeagha, Chigozie. Celestina and Ogbuebuna, Jacinta Ogechukwu [Nigeria]



This study evaluated the Pharmacological,  and nutritional activities of Chromolaela odorata  and  Tridax procumbence plant extract.A total of ninety seven (120), 8-weeks old male albino wistar rats (220g and 229g bw) were divided into different groups (control and treatment groups), 10g of pulverized plant extracts were homogenized in distilled water. The samples of the plant extract were soaked in ethanol and aqueous solvents. The percentage proximate composition of the moisture content, total ash, crude protein, total carbohydrate and crude fat were  determined in all the  plant extracts, and there was no significant different (p˂0.05). Also the mineral compositions such as  Calcium (Ca), Sodium(Na), Potassium(K), Phosphorus(P), Iron (Fe), Magnesium(Mg) and Zinc (Zn) of both the plant extracts were evaluated in (mg/kg). Moreso, the Vitamins B1(Thiamine), B2(Riboflavin), B3 (Niaci n), B6(Pyridoxine), C (Ascorbic acid), Biotin, Folic acid (Water Soluble) and Vit. A, D, E and K (Fat Soluble)   in Mg/100g of C odorata and T.procumbens extract were analysed, (P˂0.05). The effect of the plant extract on  Liver enzymes were not altered significantly (P˃0.05). Aspartate  amino transferase(AST), Alanine amino tranferase (ALT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lactate dehydrogenase (LDH) and Gamma-glutamyl Transferase (GGT) in comparison  at (7-21 days). There was  no significant reduction in haemoglobin (Hb), Packed cell volume (PCV), Mean cell volume (MCV), Mean cell haematocrit (MCH), White blood count (WBC), Lymphocyte (LYMP) and Neutrophile (NEUT) Compared with the control in all the plant extracts used. There was significant decrease (P˃0.05) in Total cholesterol (TC), Triglyceride (TG), High density lipo protein (HDL) and Low density lipoprotein (LDL), except  marginal increase in at 21days of treatment.

Keywords: Haemoglobin; Chromolaena odorata; Tridax procumbens; Optical and treatment